Journal article

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

PN Kelly, A Strasser

CELL DEATH AND DIFFERENTIATION | NATURE PUBLISHING GROUP | Published : 2011

Abstract

Tumour development requires a combination of defects that allow nascent neoplastic cells to become self-sufficient for cell proliferation and insensitive to signals that normally restrain cell growth. Among the latter, evasion of programmed cell death (apoptosis) has proven to be critical for the development and sustained growth of many, perhaps all, cancers. Apoptotic cell death is regulated by complex interactions between pro-survival members and two subgroups of pro-apoptotic members of the B-cell lymphoma-2 (Bcl-2) protein family. In this invited review article, we reminisce on the discovery of Bcl-2, the first regulator of cell death identified, we discuss the mechanisms that control ap..

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University of Melbourne Researchers

Grants

Awarded by Australian NHMRC


Awarded by Cancer Council of Victoria, NIH


Awarded by Leukemia and Lymphoma Society


Awarded by JDRF/NHMRC


Awarded by NATIONAL CANCER INSTITUTE


Funding Acknowledgements

We thank all present and past members of the apoptosis research programs at WEHI, particularly Drs. J Adams, S Cory, D Vaux, D Huang, P Colman, P Bouillet, A Harris, R Kluck and C Scott, for their outstanding contributions. Research in the authors' laboratories is supported by fellowships and grants from the Australian NHMRC (257502, 461299), Cancer Council of Victoria, NIH (CA 043540), Leukemia and Lymphoma Society (LLS SCOR 7413) and the JDRF/NHMRC (466658).