Journal article
Plasma lipoproteins and preeclampsia in women with type 1 diabetes: A prospective study
A Basu, P Alaupovic, M Wu, AJ Jenkins, Y Yu, AJ Nankervis, KF Hanssen, H Scholz, T Henriksen, B Lorentzen, T Clausen, SK Garg, MK Menard, SM Hammad, JA Scardo, JR Stanley, A Dashti, CE Aston, TJ Lyons
Journal of Clinical Endocrinology and Metabolism | Published : 2012
DOI: 10.1210/jc.2011-3255
Abstract
Context: In nondiabetic pregnancy, cross-sectional studies have shown associations between maternal dyslipidemia and preeclampsia (PE). In type 1 diabetes mellitus (T1DM),the prevalence of PE is increased 4-fold, but prospective associations with plasma lipoproteins are unknown. Objectives: The aim of this study was to define lipoprotein-related markers and potential mechanisms for PE in T1DM. Design and Settings: We conducted a multicenter prospective study in T1DM pregnancy. Patients: We studied 118 T1DM women (26 developed PE, 92 remained normotensive). Subjects were studied at three visits before PE onset [12.2 ± 1.9, 21.6 ± 1.5, and 31.5 ± 1.7 wk gestation (means ± sd)] and at term (37...
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Awarded by National Center for Research Resources
Funding Acknowledgements
This work was supported by research grants from the Juvenile Diabetes Research Foundation (JDRF 1-2001-844); National Institutes of Health (NIH) (National Center on Minority Health and Health Disparities) Grant P20 MD000528-05 (to T.J.L.); and by NIH (National Center for Research Resources) Grants M01-RR-1070 and M01-RR-14467 (to the General Clinical Research Centers at the Medical University of South Carolina and the University of Oklahoma Health Sciences Center, respectively). Support from Novo Nordisk enabled the participation of the Barbara Davis Diabetes Center for Childhood Diabetes. This publication was made possible by NIH Grant P20 RR 024215 from the Centers of Biomedical Research Excellence Program of the National Center for Research Resources.