Journal article
The latent stem cell population is retained in the hippocampus of transgenic Huntington's disease mice but not wild-type mice
TL Walker, GW Turnbull, EW Mackay, AJ Hannan, PF Bartlett
Plos One | Published : 2011
Abstract
The demonstration of the brain's ability to initiate repair in response to disease or injury has sparked considerable interest in therapeutic strategies to stimulate adult neurogenesis. In this study we examined the effect of a progressive neurodegenerative condition on neural precursor activity in the subventricular zone (SVZ) and hippocampus of the R6/1 transgenic mouse model of Huntington's disease (HD). Our results revealed an age-related decline in SVZ precursor numbers in both wild-type (WT) and HD mice. Interestingly, hippocampal precursor numbers declined with age in WT mice, although we observed maintenance in hippocampal precursor number in the HD animals in response to advancement..
View full abstractGrants
Funding Acknowledgements
This study was funded by a National Health and Medical Research Council program grant (PFB). PFB is supported by an Australian Research Council Federation Fellowship. The authors would like to thank Frank and Patsy Youngleson for a private donation, which helped to fund this work. No commercial funding was received to fund this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.