Journal article
Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: Differences between mice and man
AJ Boyle, Y Yeghiazarians, H Shih, J Hwang, J Ye, R Sievers, D Zheng, J Palasubramaniam, D Palasubramaniam, C Karschimkus, R Whitbourn, A Jenkins, AM Wilson
Journal of Translational Medicine | Published : 2011
Abstract
Background: Stem cell homing to the heart is mediated by the release of chemo-attractant cytokines. Stromal derived factor -1 alpha (SDF-1a) and monocyte chemotactic factor 1(MCP-1) are detectable in peripheral blood after myocardial infarction (MI). It remains unknown if they are produced by, and released from, the heart in order to attract stem cells to repair the damaged myocardium.Methods: Murine hearts were studied for expression of MCP-1 and SDF-1a at day 3 and day 28 following myocardial infarction to determine whether production is increased following MI. In addition, we studied the coronary artery and coronary sinus (venous) blood from patients with normal coronary arteries, stable ..
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Awarded by National Institutes of Health
Funding Acknowledgements
This study was funded by the Ellison Medical Foundation and National Institutes of Health HL90915 (AB). Dr Wilson is funded by NHMRC Neil Hamilton Fairley and University of Melbourne Bickart Fellowships. Dr Jenkins is funded by the National Heart Foundation of Australia.