Journal article
Perinatal maternal administration of lactobacillus paracasei NCC 2461 prevents allergic inflammation in a mouse model of birch pollen allergy
I Schabussova, K Hufnagl, MLK Tang, E Hoflehner, A Wagner, G Loupal, S Nutten, A Zuercher, A Mercenier, U Wiedermann
Plos One | Published : 2012
Abstract
Background: The hygiene hypothesis implies that microbial agents including probiotic bacteria may modulate foetal/neonatal immune programming and hence offer effective strategies for primary allergy prevention; however their mechanisms of action are poorly understood. We investigated whether oral administration of Lactobacillus paracasei NCC 2461 to mothers during gestation/lactation can protect against airway inflammation in offspring in a mouse model of birch pollen allergy, and examined the immune mechanisms involved. Methods: BALB/c mice were treated daily with L. paracasei in drinking water or drinking water alone in the last week of gestation and during lactation. Their offspring were ..
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Awarded by SFB grant ("Mucosal tolerance induction, a strategy for prevention and therapy of type I allergy,'' from the Austrian Science Fund
Funding Acknowledgements
This work was financially supported by Nestle (Investor Initiated Study; "Prenatal- and perinatal interventions against allergic sensitization'') and by a SFB grant ("Mucosal tolerance induction, a strategy for prevention and therapy of type I allergy,'' F0814) from the Austrian Science Fund. The funding bodies had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.