Journal article

Transition to first episode psychosis in ultra high risk populations: Does baseline functioning hold the key?

Eva Velthorst, Barnaby Nelson, Suzanne Wiltink, Lieuwe de Haan, Stephen J Wood, Ashleigh Lin, Alison R Yung



BACKGROUND: Baseline functioning has been found to be a strong predictor of transition to psychosis in ultra high risk populations. However, the time course of functioning may enhance prediction. We investigated whether there were different patterns of functioning over time and whether particular temporal patterns were related to baseline characteristics and psychosis outcome. METHOD: Functional data was assessed at baseline and after 3 to 6year follow-up in an ultra high risk sample (n=158; 92 female, mean age=19.28 (SD=3.33), range=14-29). Using the median score of the GAF and the QLS scale, a 'High' and 'Low' group (comprising of subjects functioning above or below median at both baseline..

View full abstract


Awarded by NHMRC

Awarded by European Community

Funding Acknowledgements

This project was supported by the NHMRC Program Grants (#350241 and 566529) and the Colonial Foundation. BN is supported by an NHMRC Career Development Fellowship (#1027532). LdH and EV are supported by the European Community's Seventh Framework Program (HEALTH-F2-2009-241909, Project EU-GEI). SJW is supported by the National Health and Medical Research Council (NHMRC) Career Development Awards. ARY is the recipient of NHMRC Senior Principal and Senior Research Fellowships respectively. No funding source played any role in the collection, analysis, interpretation or publication of data.