Journal article

Neurocognitive functioning in the prodrome of mania-an exploratory study

Aswin Ratheesh, Ashleigh Lin, Barnaby Nelson, Stephen J Wood, Warrick Brewer, Jennifer Betts, Michael Berk, Patrick McGorry, Alison R Yung, Andreas Bechdolf



BACKGROUND: Cognitive deficits have been well documented in individuals with bipolar disorder (BD) after the first episode of mania. However, little is known about the presence of such deficits prior to the initial manic episode. METHODS: Participants were recruited from a cohort of 416 young people who were at ultra-high risk (UHR) for psychosis and were followed up between 4 and 13 years later. The current report is of 16 participants who developed BD over a mean follow-up period of 8.2 years (UHR-BD). Baseline demographic, clinical and neurocognitive assessment scores were compared with those of 46 age and gender matched UHR subjects who did not transition to psychosis or BD over the foll..

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Awarded by National Health and Medical Research Council (NHMRC)

Awarded by German Research Foundation

Funding Acknowledgements

This study was supported by project grants from the National Health and Medical Research Council (NHMRC; grant IDs: 145627, 145737, 970598, 981112, 970391), NHMRC Programme Grant (ID: 350241), and Colonial Foundation. Dr Bechdolf was supported by a grant from the German Research Foundation (Be 3697/1-1). Dr Nelson was supported by an NHMRC Career Development Fellowship (ID: 1027532). Associate Professor Brewer was supported by a Clinical Career Development Award from the NHMRC, and A/Prof. Brewer was additionally supported by the Colonial Foundation. Prof Wood was supported by a Clinical Career Development Awards from the NHMRC (ID: 359223 and 509345). Prof. Yung is supported by a NHMRC Senior Research Fellowship.