Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies
V Beral, D Bull, K Pirie, G Reeves, R Peto, D Skegg, C LaVecchia, C Magnusson, MC Pike, D Thomas, N Hamajima, K Hirose, K Tajima, T Rohan, CM Friedenreich, EE Calle, SM Gapstur, AV Patel, RJ Coates, JM Liff Show all
Lancet Oncology | ELSEVIER SCIENCE INC | Published : 2012
BACKGROUND: Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. METHODS: Individual data from 117 epidemiological studies, including 118 964 women with invasive breast cancer and 306 091 without the disease, none of whom had used menopausal hormone therapy, were included in the analyses. We calculated adjusted relative risks (RRs) associated with menarche and menopause for breast cancer overall, and by tumour histology and by oestrogen receptor expression...View full abstract
Awarded by Cancer Research UK
Awarded by Medical Research Council
Awarded by NATIONAL CANCER INSTITUTE
Funding for this collaborative reanalysis of original data was provided by Cancer Research UK. Funding for the contributing studies is described in the publications of those studies.