Journal article

Relationship between nicotinic receptors and cognitive function in early Alzheimer's disease: A 2-[F-18]fluoro-A-85380 PET study

JR Ellis, VL Villemagne, PJ Nathan, RS Mulligan, SJ Gong, JG Chan, J Sachinidis, GJ O'Keefe, K Pathmaraj, KA Wesnes, G Savage, CC Rowe

NEUROBIOLOGY OF LEARNING AND MEMORY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2008

Abstract

Neuronal nicotinic acetylcholine receptors (nAChRs) are critical for higher order cognitive processes. Post-mortem studies suggest reductions in nAChRs (particularly the alpha(4)beta(2) subtype) with ageing and in Alzheimer's disease (AD). This study aimed to; (1) quantify nAChR distribution in vivo with 2-[18F]fluoro-A-85380 (2-FA) in 15 early AD patients compared to 14 age-matched, healthy controls (HC) and (2) correlate nAChR distribution with cognitive performance in both groups. All participants were non-smokers and underwent cognitive testing along with a dynamic PET scan after injection of 200 MBq of 2-FA. Brain regional 2-FA binding was assessed through a simplified estimation of Dis..

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Grants

Funding Acknowledgements

Research support was provided by the Austin Hospital Medical Research Fund. Fellowship support for J.R.E. was provided by the Australian Rotary Health Fund and the Monash University Postgraduate Award scheme. Fellowship support for P.J.N. was provided by the National Health and Medical Research Council (NHMRC) of Australia and the Alzheimer's Australia Research Foundation (AARF). The authors thank Drs. Michel Bottlaender and Frederic Dolle of the SHFJ PET Centre, Orsay (France) for provision of precursor and technical assistance.