Journal article
Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22
MS Cicek, JM Cunningham, BL Fridley, DJ Serie, WR Bamlet, B Diergaarde, RW Haile, L Le Marchand, TG Krontiris, HB Younghusband, S Gallinger, PA Newcomb, JL Hopper, MA Jenkins, G Casey, F Schumacher, Z Chen, MS DeRycke, AS Templeton, I Winship Show all
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI)-high tumors, or no evidence of linkage to MMR genes). Families were ascertained via the Colon Cancer Family Registry multi-site NCI-supported consortium (Colon CFR), the City of Hope Comprehensive Cancer Center, and Memorial University of Newfoundland. A total of 1,612 individuals (average 5.0..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by R01-CA104667 through cooperative agreements with the members of the Colon Cancer Family Registry and PIs. Collaborating centers include the Australian Colorectal Cancer Family Registry (UO1 CA097735), the USC Familial Colorectal Neoplasia Collaborative Group (UO1 CA074799), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (UO1 CA074800), Ontario Registry for Studies of Familial Colorectal Cancer (UO1 CA074783), Seattle Colorectal Cancer Family Registry (UO1 CA074794), University of Hawaii Colorectal Cancer Family Registry (UO1 CA074806), and University of California Irvine Informatics Center (UO1 CA078296). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.