Journal article
Identification of a novel percent mammographic density locus at 12q24
KN Stevens, S Lindstrom, CG Scott, D Thompson, TA Sellers, X Wang, A Wang, E Atkinson, DN Rider, JE Eckel-passow, JS Varghese, T Audley, J Brown, J Leyland, RN Luben, RML Warren, RJF Loos, NJ Wareham, J Li, P Hall Show all
Human Molecular Genetics | OXFORD UNIV PRESS | Published : 2012
DOI: 10.1093/hmg/dds158
Abstract
Percent mammographic density adjusted for age and body mass index (BMI) is one of the strongest risk factors for breast cancer and has a heritable component that remains largely unidentified. We performed a three-stage genome-wide association study (GWAS) of percent mammographic density to identify novel genetic loci associated with this trait. In stage 1, we combined three GWASs of percent density comprised of 1241 women from studies at the Mayo Clinic and identified the top 48 loci (99 single nucleotide polymorphisms). We attempted replication of these loci in 7018 women from seven additional studies (stage 2). The meta-analysis of stage 1 and 2 data identified a novel locus, rs1265507 on ..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work and the MBCFS study were supported by National Institutes of Health grant R01 CA128931. The Mayo VTE was supported by National Heart, Lung and Blood Institute grant HL83131; National Human Genome Research Institute grant HG04735; National Cancer Institute grant CA92153; and Centers for Disease Control grant DD000235. MAY was supported by National Institutes of Health grants R01 CA122443, R01 CA114343 and P50 CA136393. The EPIC-Norfolk study was funded by research programme grant funding from Cancer Research UK and the Medical Research Council with additional support from the Stroke Association, British Heart Foundation, Department of Health, Research into Ageing and Academy of Medical Sciences. NHS was supported by Public Health Service Grants CA131332, CA087969, CA049449, CA089393 from the National Cancer Institute, National Institutes of Health, Department of Health and Human Services and Breast Cancer Research Fund. The NHS Phase I breast cancer cases and controls were genotyped with support from the National Cancer Institute's Cancer Markers of Susceptibility (CGEMS) initiative. SASBAC was supported by National Institutes of Health grant R01 CA58427; Marit and Hans Rausing's Initiative Against Breast Cancer; the W81XWH-05-1-0314 Innovator Award; US Department of Defense Breast Cancer Research Program; Office of the Congressionally Directed Medical Research Programs; and the Agency for Science, Technology and Research (A*STAR). Genotyping in the TORONTO/MELBOURNE subjects was supported by the Campbell Family Institute for Breast Cancer Research. Support was also provided by the Ontario Ministry of Health and Long Term Care. The SIBS study was supported by Cancer Research UK programme grant C1287/A10118 and Cancer Research UK project grants C1287 and C8459. D. F. E. is a Principal Research Fellow of Cancer Research UK. MCBCS was supported by Mayo Clinic Breast Cancer SPORE P50 CA116201 and National Institutes of Health grant R01 CA122340.MAYO PGRN was supported by Mayo Clinic Pharmacogenomics Research Network Center U19 GM61388 and the Mayo Clinic Breast Cancer SPORE P50 CA116201.