Pharmacological blockade of Bcl-2, Bcl-x(L) and Bcl-w by the BH3 mimetic ABT-737 has only minor impact on tumour development in p53-deficient mice
S Grabow, P Waring, L Happo, M Cook, KD Mason, PN Kelly, A Strasser
Cell Death & Differentiation | NATURE PUBLISHING GROUP | Published : 2012
Awarded by National Health and Medical Research Council
Awarded by NIH
Awarded by Leukemia and Lymphoma Society (SCOR)
Awarded by NATIONAL CANCER INSTITUTE
We thank Abbott Laboratories and Genentech Inc. for providing us with ABT-737; Dr. T Jacks for p53-deficient mice; Drs. LA O'Reilly and DC Huang, and Mr. ARD Delbridge, for advice and reagents; K McKenzie, G Siciliano, N Iannarella, L Reid and K Vella for expert animal care; B Helbert and C Young for genotyping; J Corbin for automated blood analysis; E Tsui, V Babo, K Weston, Y Hoang and S Hasanein for histology, and D Quilici, T Nikolaou and G Thomas for gamma-irradiation. This work was supported by grants and fellowships from the Cancer Council of Victoria (to PNK), the National Health and Medical Research Council (Program Grant no. 461221; NHMRC Australia Fellowship), the NIH (CA43540) and the Leukemia and Lymphoma Society (SCOR Grant no. 7413), University of Melbourne International Research Scholarship, University of Melbourne International Fee Remission Scholarship, Cancer Therapeutics CRC Top-up Scholarship (last three to SG) and operational infrastructure grants through the Australian Government IRISS and the Victorian State Government OIS.