HFE C282Y Homozygosity Is Associated with an Increased Risk of Total Hip Replacement for Osteoarthritis
Yuanyuan Wang, Lyle C Gurrin, Anita Wluka, Nadine A Bertalli, Nicholas J Osborne, Martin B Delatycki, Graham G Giles, Dallas R English, John L Hopper, Julie A Simpson, Stephen Graves, Katrina J Allen, Flavia M Cicuttini
SEMINARS IN ARTHRITIS AND RHEUMATISM | W B SAUNDERS CO-ELSEVIER INC | Published : 2012
OBJECTIVE: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study. METHODS: The Melbourne Collaborative Cohort Study recruited participants between 1990 and 1994. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 27,848) were genotyped for the HFE C282Y mutation. Total hip and knee replacements for osteoarthritis during 2001 to 2009 were ascertai..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC Public Health (Australia)
The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and Cancer Council Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057), capacity building grant (251533), and enabling grant (396414) and was further supported by infrastructure provided by The Cancer Council of Victoria. Dr Wang is the recipient of NHMRC Public Health (Australia) Fellowship (NHMRC 465142). Dr Wluka is the recipient of NHMRC Career Development Award (NHMRC 545876). Dr Delatycki is the recipient of a NHMRC Practitioner Fellowship (NHMRC 546452).