Journal article

Increased fasting serum glucose concentration is associated with adverse knee structural changes in adults with no knee symptoms and diabetes

Miranda L Davies-Tuck, Yuanyuan Wang, Anita Wluka, Patricia A Berry, Graham G Giles, Dallas R English, Flavia M Cicuttini



OBJECTIVE: There is evidence to suggest that elevated glucose concentration and clinical diabetes are associated with osteoarthritis (OA). However, the association may be confounded by knee symptoms, concomitant treatment for OA or diabetes. We performed a longitudinal cohort study to examine the relationship between serum glucose concentration and knee structure in adults with no knee symptoms or diabetes. METHODS: 179 participants who had fasting serum glucose measurements at 1990-4, with no knee symptoms or diabetes (physician-diagnosed or fasting serum glucose ≥7 mmol/L), underwent knee MRI in 2003-4 and 2 years later. Body mass index was measured at 1990-4 and 2003-4. Cartilage volume a..

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Awarded by National Health and Medical Research Council (NHMRC)

Funding Acknowledgements

The Melbourne Collaborative Cohort Study recruitment was funded by VicHealth and Cancer Council Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057), capacity building grant (251533), and enabling grant (396414), and was further supported by infrastructure provided by Cancer Council Victoria. We would like to acknowledge the NHMRC (project grant 334150) for support. Dr. Davies-Tuck is the recipient of a Monash Bridging Fellowship. Dr. Wang is the recipient of an NHMRC Public Health Fellowship (465142). Dr. Wluka is the recipient of an NHMRC Career Development Award (Clinical Level 1, 545876). Ms. Berry is the recipient of an Australian Postgraduate Award PhD Scholarship.