Journal article
Synthesis and X-ray crystal structure of cynandione B analogues
LPT Hong, JM White, CD Donner
Australian Journal of Chemistry | CSIRO PUBLISHING | Published : 2012
DOI: 10.1071/CH11364
Abstract
The synthesis of analogues of cynandione B, a phenolic acetophenone from Cynanchum taiwanianum, is described. The one-step conversion of benzochromenones to the heptacyclic spiroacetal core of cynandione B using methylmagnesium bromide is investigated and structural requirements for this novel transformation established. X-ray crystal structure analysis has established the relative configuration in these unusual heterocycles. Journal compilation © CSIRO 2011.
Grants
Funding Acknowledgements
Financial support from the Australian Research Council through the Centres of Excellence program is gratefully acknowledged. Professor Carl Schiesser, The University of Melbourne, is acknowledged for useful discussions.