Early and delayed tranilast treatment reduces pathological fibrosis following myocardial infarction

Abstract

Background: Tranilast has been shown to inhibit TGFβ1-related fibrosis and organ failure in various disease models. We sought to examine the effects of tranilast on left ventricular (LV) remodelling post-MI. Methods: Following coronary artery ligation, Sprague Dawley rats were randomised to receive tranilast (300. mg/kg/d, p.o.) or vehicle control over one of two treatment periods: (1) from 24. h until seven days post-MI, (2) from seven days to 28 days post-MI. Cardiac tissue was harvested for molecular, immunohistochemical and cell culture analyses. Results: Tranilast treatment of MI rats from 24. h until seven days post-MI reduced myocardial collagen content, α1 (I) procollagen, TGFβ1 and ..