Journal article
Dynamic synchrotron imaging of diabetic rat coronary microcirculation in vivo
MJ Jenkins, AJ Edgley, T Sonobe, K Umetani, DO Schwenke, Y Fujii, RD Brown, DJ Kelly, M Shirai, JT Pearson
Arteriosclerosis Thrombosis and Vascular Biology | Published : 2012
Abstract
Objective-: In diabetes, long-term micro-and macrovascular damage often underlies the functional decline in the cardiovascular system. However, it remains unclear whether early-stage diabetes is associated with in vivo functional impairment in the coronary microvasculature. Synchrotron imaging allows us to detect and quantify regional differences in resistance microvessel caliber in vivo, even under conditions of high heart rate. Methods and Results-: Synchrotron cine-angiograms of the coronary vasculature were recorded using anesthetized Sprague-Dawley rats 3 weeks after treatment with vehicle or streptozotocin (diabetic). In the early diabetic state, in the presence of nitric oxide and pro..
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Awarded by Japan Society for the Promotion of Science
Funding Acknowledgements
[ "Experiments were performed at the Japan Synchrotron Radiation Research Institute (SPring-8, BL28B2, Proposals 2009A1333 and 2010A1207) with approval from the Animal Experiment Review Committee. Darren J. Kelly is supported by the National Health and Medical Research Council Senior Fellowship.", "The authors acknowledge support from the Access to Major Research Facilities Programme, which is a component of International Science Linkages Programme (Australian Nuclear Science and Technology Organisation, AMRFP proposal AS-IA101), the Ministry of Health, Labour and Welfare, and a Grant-in-Aid (A) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (No. 20590242, 23650213, and 23249038). This study was also supported by a National Health and Medical Research Program Grant (No. 546272)." ]