Journal article

Gene-expression analysis of early- and late-maturation-stage rat enamel organ

Rodrigo S Lacruz, Charles E Smith, Yi-Bu Chen, Michael J Hubbard, Joseph G Hacia, Michael L Paine

EUROPEAN JOURNAL OF ORAL SCIENCES | WILEY | Published : 2011

Abstract

Enamel maturation is a dynamic process that involves high rates of mineral acquisition, associated fluctuations in extracellular pH, and resorption of extracellular enamel proteins. During maturation, ameloblasts change from having a tall, thin, and highly polarized organization, characteristic of the secretory stage, to having a low columnar and widened morphology in the maturation stage. To identify potential differences in gene expression throughout maturation, we obtained enamel organ epithelial cells derived from the early- and late-maturation stages of rat incisor and analyzed the global gene-expression profiles at each stage. Sixty-three candidate genes were identified as having poten..

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University of Melbourne Researchers