Journal article
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study
DH Cribbs, NC Berchtold, V Perreau, PD Coleman, J Rogers, AJ Tenner, CW Cotman
Journal of Neuroinflammation | Published : 2012
Abstract
Background: This study undertakes a systematic and comprehensive analysis of brain gene expression profiles of immune/inflammation-related genes in aging and Alzheimer's disease (AD).Methods: In a well-powered microarray study of young (20 to 59 years), aged (60 to 99 years), and AD (74 to 95 years) cases, gene responses were assessed in the hippocampus, entorhinal cortex, superior frontal gyrus, and post-central gyrus.Results: Several novel concepts emerge. First, immune/inflammation-related genes showed major changes in gene expression over the course of cognitively normal aging, with the extent of gene response far greater in aging than in AD. Of the 759 immune-related probesets interroga..
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Awarded by National Institutes of Health
Funding Acknowledgements
Funding support for this study was provided by National Institutes of Health grants RO1 AG023173, P50 AG16573 to CWC, and PO1 AG000538 to CWC and DHC, and an Alzheimer's Association grant IIRG11-204835 (DHC). We are grateful to the Sun Health Research Institute Brain Donation Program of Sun City, AZ for the provision of human brain tissue samples with support by the following grants: P30 AG19610, contract 211002 (AZ ARC) and the Arizona Biomedical Research Commission (contracts 4001, 0011 and 05-901 to the AD PDC). In addition, we thank the tissue repositories at the Institute for Memory Impairments and Neurological Disorder at the University of California at Irvine, University of Rochester, Johns Hopkins University, University of Maryland, University of Pennsylvania, and University of Southern California for contributing tissue for this study.