Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

Grants

Funding Acknowledgements

Funding support for this study was provided by National Institutes of Health grants RO1 AG023173, P50 AG16573 to CWC, and PO1 AG000538 to CWC and DHC, and an Alzheimer's Association grant IIRG11-204835 (DHC). We are grateful to the Sun Health Research Institute Brain Donation Program of Sun City, AZ for the provision of human brain tissue samples with support by the following grants: P30 AG19610, contract 211002 (AZ ARC) and the Arizona Biomedical Research Commission (contracts 4001, 0011 and 05-901 to the AD PDC). In addition, we thank the tissue repositories at the Institute for Memory Impairments and Neurological Disorder at the University of California at Irvine, University of Rochester, Johns Hopkins University, University of Maryland, University of Pennsylvania, and University of Southern California for contributing tissue for this study.