Journal article

Severe asthma in adults: what are the important questions?

Pascal Chanez, Sally E Wenzel, Gary P Anderson, Josep M Anto, Elisabeth H Bel, Louis-Philippe Boulet, Christopher E Brightling, William W Busse, Mario Castro, Babro Dahlen, Sven Erik Dahlen, Leo M Fabbri, Stephen T Holgate, Marc Humbert, Mina Gaga, Guy F Joos, Bruce Levy, Klaus F Rabe, Peter J Sterk, Susan J Wilson Show all

Journal of Allergy and Clinical Immunology | Published : 2007


The term severe refractory asthma (SRA) in adults applies to patients who remain difficult to control despite extensive re-evaluation of diagnosis and management following an observational period of at least 6 months by a specialist. Factors that influence asthma control should be recognized and adequately addressed prior to confirming the diagnosis of SRA. This report presents statements according to the literature defining SRA in order address the important questions. Phenotyping SRA will improve our understanding of mechanisms, natural history, and prognosis. Female gender, obesity, and smoking are associated with SRA. Atopy is less frequent in SRA, but occupational sensitizers are common..

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University of Melbourne Researchers