Journal article
Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats
Q Liu, M Zhang, WJ Qin, YT Wang, YL Li, L Jing, JX Li, AJ Lawrence, JH Liang
Brain Research | ELSEVIER | Published : 2012
Abstract
Behavioral sensitization to a single morphine injection is a unique model to study the neuroanatomical substrates of long-lasting behavioral plasticity associated with opioid reward and abuse. Earlier observations have demonstrated that septal nuclei are critically involved in the processes of reward, learning and memory. In the present study, we investigated the effects of septal nuclei lesions on behavioral sensitization to a single morphine injection, morphine induced conditioned place preference and antinociception in rats. Behavioral sensitization was established by a single injection of 3-30 mg/kg morphine in rats. Bilateral electrical lesions of septal nuclei were carried out 7 days b..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was supported by the National Nature Science Foundation of China, no. 30870894, the National Basic Research Program of China, no. 2009CB522000, and the National Key Technology R&D Program in the 12th Five Year Plan of China, no. 2011BAK04B08. AJL is a Principal Research Fellow supported by the National Health & Medical Research Council (Australia).