The COMT Val158 allele is associated with impaired delayed-match-to- sample performance in ADHD
Natasha Matthews, Alasdair Vance, Tarrant DR Cummins, Joseph Wagner, Amanda Connolly, Jacqueline Yamada, Paul J Lockhart, Ajay Panwar, Robyn H Wallace, Mark A Bellgrove
Behavioral and Brain Functions | BMC | Published : 2012
BACKGROUND: This study explored the association between three measures of working memory ability and genetic variation in a range of catecholamine genes in a sample of children with ADHD. METHODS: One hundred and eighteen children with ADHD performed three working memory measures taken from the CANTAB battery (Spatial Span, Delayed-match-to-sample, and Spatial Working Memory). Associations between performance on working memory measures and allelic variation in catecholamine genes (including those for the noradrenaline transporter [NET1], the dopamine D4 and D2 receptor genes [DRD4; DRD2], the gene encoding dopamine beta hydroxylase [DBH] and catechol-O-methyl transferase [COMT]) were investi..View full abstract
The authors would like to acknowledge the assistance of Ms Karen Dally and Dr Ziarah Hawi. This work was supported by grants from National Health and Medical Research Council (NHMRC) of Australia to MAB, RHW, and AV and from a NARSAD Young Investigator Award to MAB. MAB receives Research Fellowship support under a Career Development Award from the NHMRC, Australia.