Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas
Shu-Shong Hsu, Chih-Hao Chen, Guei-Sheung Liu, Ming-Hong Tai, Jyh-Seng Wang, Jain-Ching Wu, Mei-Lang Kung, Elsa C Chan, Li-Feng Liu
JOURNAL OF NEURO-ONCOLOGY | SPRINGER | Published : 2012
Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery...View full abstract
Awarded by National Science Council (NSC)
Awarded by Kaohsiung Veterans General Hospital
Awarded by I-Shou University, Taiwan
This work was supported in part by grants from the National Science Council (NSC 95-2311-B-214-001; NSC 96-2314-B-075B-007; NSC 98-2314-B-075B-006-MY3), Kaohsiung Veterans General Hospital(VGHKS-98-043; VGHKS-97-A010), and I-Shou University (ISU98-04-05), Taiwan.