Journal article

Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas

Shu-Shong Hsu, Chih-Hao Chen, Guei-Sheung Liu, Ming-Hong Tai, Jyh-Seng Wang, Jain-Ching Wu, Mei-Lang Kung, Elsa C Chan, Li-Feng Liu

JOURNAL OF NEURO-ONCOLOGY | SPRINGER | Published : 2012

Abstract

Hepatoma-derived growth factor (HDGF) is a neurotrophic factor found in mouse spinal cord and hippocampal neurons. In various malignant tumors, the role of HDGF in tumor progression and its use as a diagnostic biomarker or therapeutic target have been extensively explored. However, the prognostic function and mitogenic role of HDGF in gliomagenesis are yet to be verified. In this study, we found a significant incidence of HDGF prevalence between the different pathological types and stages of glioma in 105 patients. We also found a prognostic significance in 41 glioblastoma multiforme (GBM) patients, with prevalence of nuclear HDGF predicting short survival of patients with GBM after surgery...

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