Changes in plasma creatinine concentration after cardiac anesthesia with isoflurane, propofol, or sevoflurane: A randomized clinical trial

Abstract

Background: Renal impairment often follows cardiac surgery. The authors investigated whether sevoflurane produces greater increases in plasma creatinine concentration than isoflurane or propofol after elective coronary artery surgery. Methods: As part of maintenance anesthesia, including during cardiopulmonary bypass, patients were randomly allocated to receive one of three agents, isoflurane (n=118), sevoflurane (n=118), or propofol (n=118). Fresh gas flows were 31/min. The preoperative plasma creatinine concentration was subtracted from the highest creatinine concentration in the first 3 postoperative days. A median maximum increase greater than 44 μM (0.5 mg/dl) was regarded as clinically..