Journal article
Atrial remodeling in obstructive sleep apnea: Implications for atrial fibrillation
H Dimitri, M Ng, AG Brooks, P Kuklik, MK Stiles, DH Lau, N Antic, A Thornton, DA Saint, D McEvoy, R Antic, JM Kalman, P Sanders
Heart Rhythm | ELSEVIER SCIENCE INC | Published : 2012
Abstract
Background: There is a known association between obstructive sleep apnea (OSA) and atrial fibrillation (AF); however, how OSA affects the atrial myocardium is not well described. Objective: To determine whether patients with OSA have an abnormal atrial substrate. Methods: Forty patients undergoing ablation of paroxysmal AF and in sinus rhythm (20 with OSA [apneahypopnea index < 15] and 20 reference patients with no OSA [apneahypopnea index < 15] by polysomnography) were studied. Multipolar catheters were positioned at the lateral right atrium (RA), coronary sinus, crista terminalis, and RA septum to determine the effective refractory period at 5 sites, conduction time along linear catheters ..
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Funding Acknowledgements
Dr Dimitri is supported by Postgraduate Medical Scholarships from the Cardiac Society of Australia and New Zealand and jointly by the National Heart Foundation of Australia and the National Health and Medical Research Council of Australia. Dr Brooks, Dr Kuklik, and Dr Sanders are funded by the National Heart Foundation of Australia. Dr Stiles is supported by the National Heart Foundation of New Zealand and the Dawes Scholarship from the Royal Adelaide Hospital. Dr Lau is supported by a Postdoctoral Fellowship from the National Health and Medical Research Council of Australia. Dr Sanders reports having served on the advisory board of Bard Electrophysiology, Biosense-Webster, Medtronic, St Jude Medical, Sanofi-Aventis, and Merck, Sharpe and Dohme. Dr Sanders reports having received lecture fees and research funding from Bard Electrophysiology, Biosense-Webster, Medtronic, and St Jude Medical. This article was presented in part at the Annual Scientific Sessions of the Heart Rhythm Society, May 2011, San Francisco, USA, and published in abstract form in Heart Rhythm 2011; 8:S244.