Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice
Saleela M Ruwanpura, Louise McLeod, Alistair Miller, Jessica Jones, Ross Vlahos, Georg Ramm, Anthony Longano, Philip G Bardin, Steven Bozinovski, Gary P Anderson, Brendan J Jenkins
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | AMER PHYSIOLOGICAL SOC | Published : 2012
Interleukin (IL)-6 is a potent immunomodulatory cytokine that is associated with emphysema, a major component of chronic obstructive pulmonary disease (COPD). IL-6 signaling via the gp130 coreceptor is coupled to multiple signaling pathways, especially the latent transcription factor signal transducer and activator of transcription (Stat)3. However, the pathological role of endogenous gp130-dependent Stat3 activation in emphysema is ill defined. To elucidate the role of the IL-6/gp130/Stat3 signaling axis in the cellular and molecular pathogenesis of emphysema, we employed a genetic complementation strategy using emphysematous gp130(F/F) mice displaying hyperactivation of endogenous Stat3 th..View full abstract
This work was supported in part by a research grant from the National Health and Medical Research Council (NHMRC), Australia (to B. J. Jenkins and P. G. Bardin), as well as the Operational Infrastructure Support Program by the Victorian Government of Australia. S. M. Ruwanpura is supported by a NHMRC Postdoctoral Training Fellowship. B. J. Jenkins is supported by both a Senior Medical Research Fellowship awarded by the Sylvia and Charles Viertel Charitable Foundation, and a Monash University Fellowship.