Early-onset versus late-onset nonanastomotic biliary strictures post liver transplantation: Risk factors reflect different pathogenesis

Abstract

Nonanastomotic biliary strictures (NAS) cause significant morbidity post liver transplantation. Timing of stricture development varies considerably, but the relationship between timing of stricture onset and aetiology has not been fully elucidated. Database analysis was performed on all adult patients undergoing liver transplantation between 1st January 1990 and 31st May 2008. Diagnosis of NAS required demonstration on at least two radiological studies. Early NAS were defined as developing 1 year post transplant (minimum 10-year follow- up). Ninety-six of 397 patients developed NAS (24%); 54 were early-onset NAS (56%) and 42 late-onset NAS (44%). Primary sclerosing cholangitis (PSC) was the ..