Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L Paternoster; M Standl; CM Chen; A Ramasamy; K Bøpnnelykke; L Duijts; MA Ferreira; AC Alves; JP Thyssen; E Albrecht; H Baurecht; B Feenstra; PMA Sleiman; P Hysi; NM Warrington; I Curjuric; R Myhre; JA Curtin; MM Groen-Blokhuis; M Kerkhof; A Sääf; A Franke; D Ellinghaus; R Fölster-Holst; E Dermitzakis; SB Montgomery; H Prokisch; K Heim; AL Hartikainen; A Pouta; J Pekkanen; AIF Blakemore; JL Buxton; M Kaakinen; DL Duffy; PA Madden; AC Heath; GW Montgomery; PJ Thompson; MC Matheson; P Le Souëf; BS Pourcain; GD Smith; J Henderson; JP Kemp; NJ Timpson; P Deloukas; SM Ring; HE Wichmann; M Müller-Nurasyid; N Novak; N Klopp; E Rodríguez; W McArdle; A Linneberg; T Menné; EA Nohr; A Hofman; AG Uitterlinden; CM Van Duijn; F Rivadeneira; JC De Jongste; RJP Van Der Valk; M Wjst; R Jogi; F Geller; HA Boyd; JC Murray; C Kim; F Mentch; M March; M Mangino; TD Spector; V Bataille; CE Pennell; PG Holt; P Sly; CMT Tiesler; E Thiering; T Illig; M Imboden; W Nystad; A Simpson; JJ Hottenga; D Postma; GH Koppelman; HA Smit; C Söderhäll; B Chawes; E Kreiner-Møpller; H Bisgaard; E Melén; DI Boomsma; A Custovic; B Jacobsson; NM Probst-Hensch; LJ Palmer; D Glass; H Hakonarson; M Melbye

Journal article

Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis

L Paternoster, M Standl, CM Chen, A Ramasamy, K Bøpnnelykke, L Duijts, MA Ferreira, AC Alves, JP Thyssen, E Albrecht, H Baurecht, B Feenstra, PMA Sleiman, P Hysi, NM Warrington, I Curjuric, R Myhre, JA Curtin, MM Groen-Blokhuis, M Kerkhof Show all

Nature Genetics | Published : 2012

DOI: 10.1038/ng.1017

Abstract

Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10 -13) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10 -9..

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