Journal article
Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis
SC Kolbe, M Marriott, A van der Walt, J Fielding, A Klistorner, PJ Mitchell, H Butzkueven, TJ Kilpatrick, GF Egan
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2012
DOI: 10.1167/iovs.11-8864
Abstract
PURPOSE. To compare white matter (WM) injuries associated with vision loss in multiple sclerosis (MS) and optic neuritis (ON). METHODS. Twenty-three patients with clinically definite relapsing-remitting MS and chronic unilateral ON and 14 neurologically healthy volunteers were monocularly tested with Sloan 100%, 2.5%, and 1.25% contrast visual acuity charts. Primary visual pathway and whole-brain WM injury were assessed with optical coherence tomography (OCT) and diffusion tensor imaging (DTI). OCT and DTI correlates of high- and low-contrast visual impairment were identified using correlation analyses. RESULTS. The MS patients displayed significantly reduced retinal nerve fiber layer (RNFL)..
View full abstractGrants
Awarded by Australian National Health and Medical Research Council (NHMRC)
Awarded by MS Research Australia/Trish MS Foundation/NHMRC
Funding Acknowledgements
Supported by an unrestricted research grant from Biogen Idec; Principal Research Fellowship Grant 400317 from the Australian National Health and Medical Research Council (NHMRC) (GFE); Grant 400476 from the Joint MS Research Australia/Trish MS Foundation/NHMRC Betty Cuthbert Fellowship (HB); the MS Research Australia Postdoctoral Fellowship (SCK); Charityworks for MS, Melbourne; and the Neurosciences Victoria Neuroinformatics Platform.