Journal article
Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease
G Verdile, SM Laws, D Henley, D Ames, AI Bush, KA Ellis, NG Faux, VB Gupta, QX Li, CL Masters, KE Pike, CC Rowe, C Szoeke, K Taddei, VL Villemagne, RN Martins
Molecular Psychiatry | NATURE PUBLISHING GROUP | Published : 2014
DOI: 10.1038/mp.2012.147
Abstract
Testosterone and gonadotropins have been associated with cognitive decline in men and the modulation of β amyloid (Aβ) metabolism. The relatively few studies that have investigated whether changes in one or a combination of these hormones influence Aβ levels have focused primarily on plasma Aβ 1-40 and not on the more pathogenic Aβ 1-42. Currently, no study has investigated whether these hormones are associated with an increase in brain amyloid deposition, ante mortem. Through the highly characterised Australian imaging, biomarkers and lifestyle study, we have determined the impact of these hormones on plasma Aβ levels and brain amyloid burden (Pittsburgh compound B (PiB) retention). Spearma..
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Funding Acknowledgements
Core funding for this study was provided by CSIRO, which was supplemented by 'in kind' contributions from study partners. This research is supported by the Science and Industry Endowment Fund. The AIBL investigators thank Richard Head of CSIRO for initiating and facilitating the AIBL collaboration. The study also received support from the National Health and Medical Research Council via the Dementia Collaborative Research Centres programme. Pfizer International has contributed financial support to assist with the analysis of blood samples and to further the AIBL research programme. The McCusker Alzheimer's Research Foundation Inc. contributed financial and in kind support to AIBL. We thank all those who took part as subjects in the study for their commitment and dedication to helping advance research into the early detection and causation of AD. The authors acknowledge the financial support of the CRC for Mental Health. The Cooperative Research Centre (CRC) programme is an Australian government initiative.