Journal article

Brain receptors, renin secretion, and renal sodium retention in conscious sheep.

DR Mouw, SF Abraham, JR Blair-West, JP Coghlan, DA Denton, JS McKenzie, MJ McKinley, BA Scoggins

Am J Physiol | Published : 1974


Cerebrospinal fluid (CSF) Na concentration was measured in conscious sheep before and after Na depletion; progressive Na depletion was associated with significant decrements in CSF Na concentration. In addition, ventriculocisternal perfusion was performed in unanesthetized sheep. The low Na solution used was identical to the control solution (artificial sheep CSF) minus 25 meq/l NaCl. Low Na perfusion caused increments in urine flow and plasma renin concentration, and decreased Na excretion, while blood aldosterone concentration was unaffected. No changes in blood pressure, heart rate, respiratory rate, hematocrit, or plasma Na concentration were observed during low Na perfusion. It is concl..

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