Journal article
Urinary proteomics for early diagnosis in diabetic nephropathy
P Zürbig, G Jerums, P Hovind, RJ MacIsaac, H Mischak, SE Nielsen, S Panagiotopoulos, F Persson, P Rossing
Diabetes | Published : 2012
DOI: 10.2337/db12-0348
Open access
Abstract
Diabetic nephropathy (DN) is a progressive kidney disease, a well-known complication of long-standing diabetes. DN is the most frequent reason for dialysis in many Western countries. Early detection may enable development of specific drugs and early initiation of therapy, thereby postponing/preventing the need for renal replacement therapy. We evaluated urinary proteome analysis as a tool for prediction of DN. Capillary electrophoresis-coupled mass spectrometry was used to profile the low-molecular weight proteome in urine. We examined urine samples from a longitudinal cohort of type 1 and 2 diabetic patients (n = 35) using a previously generated chronic kidney disease (CKD) biomarker classi..
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Awarded by European Commission
Funding Acknowledgements
This work was supported in part by European Union funding through SysKID (HEALTH-F2-2009-241544) and by grant 0315896B (NephAge) from Bundesministerium fur Bildung und Forschung (BMBF). P.Z. is employed by mosaiques diagnostics, and H.M. is cofounder and coowner of mosaiques diagnostics, the company that developed and established the CE-MS proteome analysis of human urine. P.R. has received speaker's honorarium from Novartis, sanofi-aventis, Boehringer Ingelheim, and Merck (MSD) and research grants from Novartis. F.P. has received speaker's honorarium and research grants from Novartis. No other potential conflicts of interest relevant to this article were reported.