Is nonalbuminuric renal insufficiency in type 2 diabetes related to an increase in intrarenal vascular disease?
Richard J MacIsaac, Sianna Panagiotopoulos, Karen J McNeil, Trudy J Smith, Con Tsalamandris, Huming Hao, P Geoffrey Matthews, Merlin C Thomas, David A Power, George Jerums
Diabetes Care | Published : 2006
OBJECTIVE: To investigate the role of intrarenal vascular disease in the pathogenesis of nonalbuminuric renal insufficiency in type 2 diabetes. RESEARCH DESIGN AND METHODS: We studied 325 unselected clinic patients who had sufficient clinical and biochemical information to calculate an estimated glomerular filtration rate (eGFR) using the Modified Diet in Renal Disease six-variable formula, at least two estimations of urinary albumin excretion rates (AER), and a renal duplex scan to estimate the resistance index of the interlobar renal arteries. The resistance index, measured as part of a complications surveillance program, was compared in patients with an eGFR or=60 ml/min per 1.73 m(2) who..View full abstract