Journal article

Recognition of CD1d-restricted antigens by natural killer T cells

Jamie Rossjohn, Daniel G Pellicci, Onisha Patel, Laurent Gapin, Dale I Godfrey

NATURE REVIEWS IMMUNOLOGY | NATURE PUBLISHING GROUP | Published : 2012

Abstract

Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines following T cell receptor (TCR) activation and can shape the immune response in many different settings. There are two main NKT cell subsets: type I NKT cells are typically characterized by the expression of a semi-invariant TCR, whereas the TCRs expressed by type II NKT cells are more diverse. This Review focuses on the defining features and emerging generalities regarding how NKT cells specifically recognize self, microbial and synthetic lipid-based antigens that are presented by CD1d. Such information is vitally important to better understand, and fully harness, the therapeutic potential of NK..

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Grants

Awarded by US National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

This work was supported by the US National Institutes of Health (grants AI090450 and AI092108), Australian National Health and Medical Research Council (NHMRC) program and project grants, Cancer Council Victoria and the Australian Research Council (ARC). D.I.G. was supported by an NHMRC Senior Principal Research Fellowship; J.R. was supported by an NHMRC Australia Fellowship. O.P. was supported by an ARC Future Fellowship.