Journal article

Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders

Russell C Dale, Vera Merheb, Sekhar Pillai, Dongwei Wang, Laurence Cantrill, Tanya K Murphy, Hilla Ben-Pazi, Sophia Varadkar, Tim D Aumann, Malcolm K Horne, Andrew J Church, Thomas Fath, Fabienne Brilot

Brain | OXFORD UNIV PRESS | Published : 2012

Abstract

Recent reports of autoantibodies that bind to neuronal surface receptors or synaptic proteins have defined treatable forms of autoimmune encephalitis. Despite these developments, many cases of encephalitis remain unexplained. We have previously described a basal ganglia encephalitis with dominant movement and psychiatric disease, and proposed an autoimmune aetiology. Given the role of dopamine and dopamine receptors in the control of movement and behaviour, we hypothesized that patients with basal ganglia encephalitis and other putative autoimmune basal ganglia disorders harboured serum autoantibodies against important dopamine surface proteins. Basal ganglia encephalitis sera immunolabelled..

View full abstract

Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Pfizer Neuroscience Research Grant


Awarded by University of Sydney


Awarded by Rebecca L. Cooper for Medical Research Foundation, The Flow cytometry Core Facility of the Westmead Millennium Institute


Awarded by Cancer Institute New South Wales


Awarded by Cancer Institute New South Wales Research Equipment, The Kids Research Institute Microscope Facility


Funding Acknowledgements

Australian National Health and Medical Research Council [APP1003369]; Star Scientific Foundation (Australia); Tourette's syndrome Association (USA); Pfizer Neuroscience Research Grant [NB04.8]; The Trish MS Research Foundation and Multiple Sclerosis Research Australia; The University of Sydney [2008-00097]; Petre Foundation (Australia); the Rebecca L. Cooper for Medical Research Foundation, The Flow cytometry Core Facility of the Westmead Millennium Institute [2009-02740]; Cancer Institute New South Wales [11/REG/1-01 and 07/RIG/1-08]; Cancer Institute New South Wales Research Equipment, The Kids Research Institute Microscope Facility [10/REG/1-23 and 2009-02759]; Australian National Health and Medical Research Council [2009-02759]; the Ian Potter Foundation; the Perpetual Foundation; Ramaciotti Foundation; the Sydney Medical School Research Infrastructure Major Equipment Scheme.