Journal article
Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer
Y Wu, H Grabsch, T Ivanova, IB Tan, J Murray, CH Ooi, AI Wright, NP West, GGA Hutchins, J Wu, M Lee, J Lee, JH Koo, KG Yeoh, N Van Grieken, B Ylstra, SY Rha, JA Ajani, JH Cheong, SH Noh Show all
Gut | BMJ PUBLISHING GROUP | Published : 2013
Abstract
Objective Gastric adenocarcinoma (gastric cancer, GC) is a major cause of global cancer mortality. Identifying molecular programmes contributing to GC patient survival may improve our understanding of GC pathogenesis, highlight new prognostic factors and reveal novel therapeutic targets. The authors aimed to produce a comprehensive inventory of gene expression programmes expressed in primary GCs, and to identify those expression programmes significantly associated with patient survival. Design Using a network-modelling approach, the authors performed a large-scale meta-analysis of GC transcriptome data integrating 940 gastric transcriptomes from multiple independent patient cohorts. The auth..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported by Grants to PT from the Biomedical Research Council of Singapore (Grant 05/1/31/19/423), the National Medical Research Council of Singapore (Grant TCR/001/2007), and internal grants from the Duke-National University of Singapore Graduate Medical School, and the Cancer Sciences Institute of Singapore. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.