Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan; K Johan Rosengren; Sharon L Layfield; Ross AD Bathgate; Frances Separovic; Chrishan S Samuel; Mohammed A Hossain; John D Wade

Journal article

Identification of Key Residues Essential for the Structural Fold and Receptor Selectivity within the A-chain of Human Gene-2 (H2) Relaxin

Linda J Chan, K Johan Rosengren, Sharon L Layfield, Ross AD Bathgate, Frances Separovic, Chrishan S Samuel, Mohammed A Hossain, John D Wade

JOURNAL OF BIOLOGICAL CHEMISTRY | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2012

DOI: 10.1074/jbc.M112.409284

University of Melbourne Researchers

Frances Separovic Author Chemistry

Akhter Hossain Author Florey Department of Neuroscience and Mental Health

Chrishan Samuel Author Biochemistry and Molecular Biology

Ross Bathgate Author Biochemistry and Molecular Biology

John Wade Author Florey Department of Neuroscience and Mental Health

Related Projects (3)

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NHMRC Research Fellowship 2008 - Bathgate

I am a molecular endocrinologist determining the mechanisms by which relaxin family peptides bind to and activate their receptors and induce..

Structure-Function Relationship Of Human Relaxins.

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Grants

Awarded by National Health and Medical Research Council (NHMRC) (Australia)

Funding Acknowledgements

This research was funded by National Health and Medical Research Council (NHMRC) (Australia) Project Grants 508995 and 1023078 (to J. D. W., M. A. H., and R. A. D. B.). Studies at the Florey Neuroscience Institutes were supported by the Victorian Government's Operational Infrastructure Support Program.Recipient of Reid Trust and Florey Foundation Fellowships.