Striatal morphology as a biomarker in neurodegenerative disease
JCL Looi, M Walterfang
MOLECULAR PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2013
The striatum, comprising the caudate nucleus, putamen and nucleus accumbens, occupies a strategic location within cortico-striato-pallido-thalamic-cortical (corticostriatal) re-entrant neural circuits. Striatal neurodevelopment is precisely determined by phylogenetically conserved homeobox genes. Consisting primarily of medium spiny neurons, the striatum is strictly topographically organized based on cortical afferents and efferents. Particular corticostriatal neural circuits are considered to subserve certain domains of cognition, emotion and behaviour. Thus, the striatum may serve as a map of structural change in the cortical afferent pathways owing to deafferentation or neuroplasticity, a..View full abstract
Much of the work cited in this review has been the fruit of international interdisciplinary collaboration with many colleagues, whose contribution to such research formed part of the foundations of the arguments expounded. We thank all the following key collaborators: Phyllis Chua, Olof Lindberg, Matthew D Macfarlane, Sarah K Madsen, Christer Nilsson, Priya Rajagopalan, Martin Styner, Leif Svensson, Paul M Thompson, Danielle van Westen, Dennis Velakoulis, Lars-Olof Wahlund, Bram B Zandbelt (and all co-authors on collaborative papers in this domain). The majority of the collaborative research travel funding has been self-funded by JCLL, who also acknowledges funding/leave contributions from the Canberra Hospital Private Practice Trust Fund, and ACT Health.