Chitosan-based particles as biocompatible delivery vehicles for peptide and protein-based vaccines

Abstract

It has become increasingly recognized that polymer particle size can have a profound effect on the interactions of particle-based vaccines with antigen presenting cells (APCs) thereby influencing and modulating ensuing immune responses.With the aim of developing chitosan particle-based immunocontraceptive vaccines, we have compared the use of chitosan nano- and microparticles as delivery vehicles for vaccine candidates based on luteinising hormone-releasing hormone (LHRH). Both particle types were taken up effectively by dendritic cells with similar efficacies. Inoculation with nanoand microparticles containing conjugated peptide or protein microparticles also resulted in the induction of hi..