Psychosocial factors and uptake of risk-reducing salpingo-oophorectomy in women at high risk for ovarian cancer

B Meiser; MA Price; PN Butow; J Karatas; J Wilson; L Heiniger; B Baylock; M Charles; SA McLachlan; KA Phillips

Journal article

Psychosocial factors and uptake of risk-reducing salpingo-oophorectomy in women at high risk for ovarian cancer

B Meiser, MA Price, PN Butow, J Karatas, J Wilson, L Heiniger, B Baylock, M Charles, SA McLachlan, KA Phillips

Familial Cancer | SPRINGER | Published : 2013

DOI: 10.1007/s10689-012-9585-8

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Abstract

Bilateral risk-reducing salpingo-oophorectomy (RRSO) has been shown to significantly reduce the risk of ovarian cancer. This study assessed factors predicting uptake of RRSO. Women participating in a large multiple-case breast cancer family cohort study who were at increased risk for ovarian and fallopian tube cancer (i.e. BRCA1 or BRCA2 mutation carrier or family history including at least one first- or second-degree relative with ovarian or fallopian tube cancer), with no personal history of cancer and with at least one ovary in situ at cohort enrolment, were eligible for this study. Women who knew they did not carry the BRCA1 or BRCA2 mutation segregating in their family (true negatives) ..

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University of Melbourne Researchers

Sue-Anne McLachlan Author

Kelly Phillips Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by National Health and Medical Research Council (NHMRC) Project Grants No. 153824, 301930, 457316, 145684, 288704, and 454508 and by a National Breast Cancer Foundation and Cancer Australia Priority Driven Collaborative Cancer Research Grant (#628333). kConFab is supported by grants from the National Breast Cancer Foundation, the NHMRC, the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. Bettina Meiser receives a Career Development Award from the NHMRC. Phyllis Butow receives a Principal Research Fellowship from NHMRC. Kelly-Anne Phillips is the John Colebatch Clinical Research Fellow of the Cancer Council Victoria. We are very grateful to the many families who contribute to kConFab. We also wish to thank Lucy Stanhope, Kate Birch, Heather Thorne, Eveline Niedermayr, the kConFab research nurses and staff, and the heads and staff of the Family Cancer Clinics. We also thank Dr Adrian Bickerstaff and John Hopper for using the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) to calculate actual ovarian cancer risk.