High-Resolution Structural Characterization of a Helical alpha/beta-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-x(L)
Erinna F Lee, Jack D Sadowsky, Brian J Smith, Peter E Czabotar, Kimberly J Peterson-Kaufman, Peter M Colman, Samuel H Gellman, W Douglas Fairlie
Angewandte Chemie International Edition | WILEY-BLACKWELL | Published : 2009
Awarded by NIGMS
Awarded by NHMRC of Australia
Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
This work was supported by NIGMS grant GM-56414 (S.H.G.). J.D.S. was supported in part by an NSF Graduate Fellowship, K.J.P.-K. was supported in part by a Chemistry-Biology Interface Training Grant from NIGMS (T32 GM008505), and E.F.L., W.D.F., and P.M.C. were supported by grants and fellowships from the Cancer Council of Victoria, the NHMRC of Australia (W.D.F., P.M.C.), Australian Cancer Research Foundation (P.M.C.), and the Leukemia and Lymphoma Society (P.M.C.). Infrastructure support from NHMRC IRIIS (361646) and the Victorian State Government OIS grant is gratefully acknowledged. Crystallization trials were performed at the Bio21 Collaborative Crystallisation Centre.