Journal article
Fall in human papillomavirus prevalence following a national vaccination program
SN Tabrizi, JML Brotherton, JM Kaldor, SR Skinner, E Cummins, B Liu, D Bateson, K McNamee, M Garefalakis, SM Garland
Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2012
Abstract
Background. In April 2007, Australia became the first country to introduce a national government-funded human papillomavirus (HPV) vaccination program. We evaluated the program's impact on genotype-specific HPV infection prevalence through a repeat survey of women attending clinical services.Methods.HPV genoprevalence in women aged 18-24 years attending family planning clinics in the prevaccine period (2005-2007) was compared with prevalence among women of the same age group in the postvaccine period (2010-2011). The same recruitment and testing strategies were utilized for both sets of samples, and comparisons were adjusted for potentially confounding variables.Results.The prevalence of vac..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by Australian National Health and Medical Research Council Project Grant [APP1007685] and Anti- Cancer Council for Victoria Grant in Aid [628754]. John Kaldor and Bette Liu are supported by Fellowships from the National Health and Medical Research Council.S. N. T. was an investigator on a national HPV prevalence study that received partial, equal, and unrestricted funding from CSL Biotherapies and GlaxoSmithKline (GSK). J. M. L. B. is an investigator on an Australian Research Council Linkage Grant, for which CSL Biotherapies is a partner organization. J. M. L. B. was also an investigator on a national HPV prevalence study that received partial, equal, and unrestricted funding from CSL Biotherapies and GSK. B. L. owns shares in Commonwealth Serum Laboratories, supplier of HPV vaccine in Australia. S. M. G. has received advisory board fees and grant support from CSL and GSK, and lecture and consultancy fees from Merck. S. M. G. also reports having previously owned stock in CSL. S. G. has received grant support from Merck and GSK to carry out clinical trials for HPV/cervical cancer vaccines, and she is a member of the Merck global advisory and scientific advisory boards. S. R. S. is or has been an investigator on several clinical trials evaluating GSK's HPV vaccine, and her institution has received funding to collect data for these studies. S. R. S.'s institution has also received honoraria for Advisory Board membership, and reimbursement for attendance at conferences to present clinical trials data from GSK Biologicals; and has received unrestricted research funds from GSK Australia and CSL. All other authors report no potential conflicts.