Journal article

Regulation of sclerostin expression by paracrine and endocrine factors

NA Sims, LY Chia

Clinical Reviews in Bone and Mineral Metabolism | Springer | Published : 2012

Abstract

Sclerostin, a secreted protein encoded by the SOST gene, has been identified as a key regulator of bone formation by studies in human and mouse genetics. Expression of this protein in osteocytes has been shown to be regulated by mechanical forces, and this has been shown to be critical for the bone formation response to load. Osteocytic expression of sclerostin is also regulated by systemic hormones that are known to influence the skeleton including parathyroid hormone and calcitonin. Circulating levels of sclerostin appear to be influenced by circulating sex steroid levels. Paracrine and autocrine factors expressed by the cells within bone (osteoblasts, osteoclasts and osteocytes), includin..

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