Journal article
Using smooth particle hydrodynamics to investigate femoral cortical bone remodelling at the Haversian level
JW Fernandez, R Das, PW Cleary, PJ Hunter, CDL Thomas, JG Clement
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING | WILEY | Published : 2013
DOI: 10.1002/cnm.2503
Abstract
In the neck of the femur, about 70% of the strength is contributed by the cortical bone, which is the most highly stressed part of the structure and is the site where failure is almost certainly initiated. A better understanding of cortical bone remodelling mechanisms can help discern changes at this anatomical site, which are essential if an understanding of the mechanisms by which hips weaken and become vulnerable to fracture is to be gained. The aims of this study were to (i) examine a hypothesis that low strain fields arise because of subject-specific Haversian canal distributions causing bone resorption and reduced bone integrity and (ii) introduce the use of a meshless particle-based c..
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Funding Acknowledgements
We acknowledge funding from a Faculty Research Development Fund and Aotearoa Bioengineering fellowship (J. Fernandez), Commonwealth Scientific Industrial Research Organisation strategic funding (J. Fernandez, R. Das and P. Cleary). Financial support for imaging for D. Thomas and J. Clement including access to the Major Research Facilities Programme which is a component of the International Science Linkages Programme established under the Australian Government's innovation statement, Backing Australia's Ability. We are particularly grateful to the staff of the Victorian Institute of Forensic Medicine for assistance in the collection of material for study. At beamline 20B2 of the SPring8 Synchrotron Dr Kentaro Uesugi (Beamline Scientist) and Dr Naoto Yagi (Chief Biological Scientist) for their help with the collection of the imaging data used.