Journal article
Chest computed tomography scores are predictive of survival in patients with cystic fibrosis awaiting lung transplantation
M Loeve, WCJ Hop, M De Bruijne, PTW Van Hal, P Robinson, ML Aitken, JD Dodd, HAWM Tiddens
American Journal of Respiratory and Critical Care Medicine | Published : 2012
Abstract
Rationale: Up to one-third of patients with cystic fibrosis (CF) awaiting lung transplantation (LTX) die while waiting. Inclusion of computed tomography (CT) scores may improve survival prediction models such as the lung allocation score (LAS). Objectives: This study investigated the association between CT and survival in patients with CF screened for LTX. Methods: Clinical data and chest CTs of 411 patients with CF screened for LTX between 1990 and 2005 were collected from 17 centers. CTs were scored with the Severe Advanced Lung Disease (SALD) four-category scoring system, including the components infection/inflammation (INF), air trapping/hypoperfusion (AT), normal/hyperperfusion (NOR), a..
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Funding Acknowledgements
Supported by grants from the Sophia CF research fund; the Royal Children's Cystic Fibrosis Trust of the Royal Children's Hospital, Melbourne, Australia; the Dutch Cystic Fibrosis Foundation (NCFS); and the Italian CF Fund (IERFC). None of the sponsors were involved in the study design, data collection, analysis, interpretation of data, writing of the report, or in the decision to submit the paper for publication.