In silico prediction of antimalarial drug target candidates
Philipp Ludin, Ben Woodcroft, Stuart A Ralph, Pascal Maeser
INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE | ELSEVIER SCI LTD | Published : 2012
The need for new antimalarials is persistent due to the emergence of drug resistant parasites. Here we aim to identify new drug targets in Plasmodium falciparum by phylogenomics among the Plasmodium spp. and comparative genomics to Homo sapiens. The proposed target discovery pipeline is largely independent of experimental data and based on the assumption that P. falciparum proteins are likely to be essential if (i) there are no similar proteins in the same proteome and (ii) they are highly conserved across the malaria parasites of mammals. This hypothesis was tested using sequenced Saccharomycetaceae species as a touchstone. Consecutive filters narrowed down the potential target space of P. ..View full abstract
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Awarded by Australian Research Council
We wish to thank the Basel Computational Biology Center for runtime on their Linux cluster. SAR is funded by an Australian Research Council Future Fellowship (FT0990350). BJW was supported by a University of Melbourne Research scholarship.