Journal article
The emerging role of HDL in glucose metabolism
Brian G Drew, Kerry-Anne Rye, Stephen J Duffy, Philip Barter, Bronwyn A Kingwell
NATURE REVIEWS ENDOCRINOLOGY | NATURE PUBLISHING GROUP | Published : 2012
Abstract
A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging evidence suggests that low HDL levels might also contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) through direct effects on plasma glucose. In the past decade, animal and clinical studies have uncovered a previously undescribed spectrum of HDL actions, indicating that HDL may control glucose homeostasis through mechanisms including insulin secretion, direct glucose uptake by muscle via the AMP-activated protein kinase, and possibly enhanced insulin sensitivity. These effects are mediated by multiple cell types via mechanisms including preservation of cell function through cellular l..
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Funding Acknowledgements
The authors have received grants from the National Health and Medical Research Council of Australia and the OIS program of the Victorian State Government, Australia.