The emerging role of HDL in glucose metabolism
Brian G Drew, Kerry-Anne Rye, Stephen J Duffy, Philip Barter, Bronwyn A Kingwell
NATURE REVIEWS ENDOCRINOLOGY | NATURE PUBLISHING GROUP | Published : 2012
A low plasma level of HDL cholesterol is an atherosclerotic risk factor; however, emerging evidence suggests that low HDL levels might also contribute to the pathophysiology of type 2 diabetes mellitus (T2DM) through direct effects on plasma glucose. In the past decade, animal and clinical studies have uncovered a previously undescribed spectrum of HDL actions, indicating that HDL may control glucose homeostasis through mechanisms including insulin secretion, direct glucose uptake by muscle via the AMP-activated protein kinase, and possibly enhanced insulin sensitivity. These effects are mediated by multiple cell types via mechanisms including preservation of cell function through cellular l..View full abstract
The authors have received grants from the National Health and Medical Research Council of Australia and the OIS program of the Victorian State Government, Australia.