Journal article
Matrix metalloproteinase-3 and coronary remodelling: Implications for unstable coronary disease
Anthony J White, Stephen J Duffy, Anthony S Walton, Jer Fuu Ng, Gregory E Rice, Swati Mukheriee, James A Shaw, Garry L Jennings, Anthony M Dart, Bronwyn A Kingwell
CARDIOVASCULAR RESEARCH | ELSEVIER SCIENCE BV | Published : 2007
Abstract
OBJECTIVES: Matrix metalloproteinases (MMPs) are plausible candidates for prediction of unstable coronary syndromes. We hypothesised that the MMP-3 polymorphism (- 1171, 5A/6A) would relate to coronary plaque characteristics and unstable clinical presentation. METHODS AND RESULTS: Forty patients with de novo presentation of coronary artery disease (CAD) were classified into unstable coronary syndrome (n=19) or stable angina pectoris (n=21). On coronary intravascular ultrasound, patients with unstable disease had a greater plaque burden, more positive (outward) coronary remodelling, and all but one were MMP-3 6A allele carriers (p=0.027 compared with stable). The relationship between the 6A a..
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