Journal article

MT-MMPs in pre-eclamptic placenta: Relationship to soluble endoglin production

TJ Kaitu'u-Lino, L Tuohey, L Ye, K Palmer, M Skubisz, S Tong

PLACENTA | W B SAUNDERS CO LTD | Published : 2013

Abstract

INTRODUCTION: Pre-eclampsia is a serious complication of pregnancy, characterized by severe endothelial dysfunction resulting in hypertension, proteinuria and maternal end-organ damage. Soluble endoglin is an anti-angiogenic factor released from placenta that has been linked to severe pre-eclampsia. We recently reported MMP-14 is capable of cleaving endoglin to release soluble endoglin from placenta, however inhibition studies only partially repressed production. To this end we have sought to identify other proteases that mediate endoglin shedding from placenta. MMP-14 is one of six-membrane-type (MT-) MMPs, a sub-family of the MMP superfamily, so named because they are membrane bound. MMP-1..

View full abstract

Grants

Awarded by National Health and Medical Research Council of Australia


Funding Acknowledgements

The National Health and Medical Research Council of Australia provided salary support (#490970 to S.T.; #490995 to T.K.). Project funding was provided by the ANZ Trustees of Medical Research and Technology Australia, the University of Melbourne and the National Health and Medical Research Council of Australia (#1048707). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.