Journal article

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

DR Thakker, F Natt, D Husken, H van der Putten, R Maier, D Hoyer, JF Cryan

MOLECULAR PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2005

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressant drugs that increase the extracellular levels of serotonin by blocking the reuptake activity of the serotonin transporter (SERT). Although SSRIs elevate brain serotonergic neurotransmission acutely, their full therapeutic effects involve neurochemical adaptations that emerge following chronic drug administration. The adaptive downregulation of SERT has recently been implicated in the therapeutic response of SSRIs. Interestingly, studies using SERT-knockout mice reveal somewhat paradoxical depression-related effects, probably specific to the downregulation of SERT during early development. However, the behavioral si..

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University of Melbourne Researchers